Brain Barriers Training -12 PhD students positions available on brain barrier research
Research in BtRAIN (www.btrain-2020.eu) is dedicated to create and disseminate unique knowledge on the vertebrate brain barrier signature genes and their specific role in regulating brain barrier function in development, health, ageing and disease. BtRAIN will train a new generation of young researchers to think out of the box and to bridge disciplinary interfaces by providing trans-disciplinary training in research and technological development in the field of brain barriers research
To achieve such a holistic overview on the biology of the vertebrate brain barriers, BtRAIN provides a unique trans-disciplinary and trans-sectorial environment, combining the expertise of clinical and non-clinical researchers in biomedical disciplines (developmental biology, vascular and cell biology, physiology, pharmacology, neuroimmunology) and technologies (chemistry, bioenigneering and imaging of the brain barriers) with that of bioinformatics from the academic and non-academic sector. BtRAIN fosters intense contacts of 12 academic and 6 non-academic partners from 7 EU countries, CH, USA and the European Network Brains4Brain.
The following BtRAIN projects are available
Project 1: In vitro models of the blood brain-barrier (BBB) and applications in pharmacological and toxicological screenings
Project 2: In vitro models of the blood-brain and blood- cerebrospinal fluid (CSF) barriers using an integrated microfluidic device
Project 3: Comparison of mouse and zebrafish cerebral endothelial cell transcriptomes and functional investigation of conserved pathways governing brain angiogenesis and BBB formation
Project 4: Integrative meta-analysis of public and novel vertebrate BBB omics data and establishment of the BBBhub platform
Project 5: Role of the orphan G-protein-coupled receptor Gpr126 signalling in the development of the blood-brain barrier
Project 6: Age-induced changes in gene and microRNA expression at the mouse blood-brain barrier
Project 7: Blood-brain barrier derived non-conding RNAs as functional biomarkers for the aging BBB versus the BBB in Alzheimer’s Disease
Project 8: Brain endothelial mechanisms directing the cellular pathway of T cell migration across the BBB
Project 9: Contribution of the BBB in amyloid-b biology in Alzheimer’s disease
Project 10: Exploring CD4+ T cells as carriers to mediate transport of drugs across the blood-brain barrier
Project 11: Role of different receptors in promoting pathogen and leukocyte migration across the brain cerebrospinal fluid barrier (BCSFB) in meningitis
Project 12: Molecular control of the human brain barriers in health and neuroinflammation
Eligibility Criteria
BtRAIN is a research fellowship programme for ‚Early Stage Researchers (ESR)’. If you intend to do your PhD and you have less than 4 years research experience, you might apply for a fellowship. Applicants will have to meet the Marie Sklodowska-Curie eligibility criteria (http://ec.europa.eu/research/participants/data/ref/h2020/wp/2014_2015/main/h2020-wp1415-msca_en.pdf p40-41).
Pre-requisites for the candidates
University Master Degree in any discipline in the Life Sciences, Medical Sciences, or in Biomedical Engineering, Chemistry or Bioinformatics, depending on the project applied for
Mobility during the program to fullfill the requirements for secondments
Ability to work in an international team and to meet deadlines
Ability to analyze, integrate and communicate large amounts of data
Ability to multi-task
Submit your application now: http://www.btrain-2020.eu/application
